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Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's by Charles Piller
English | February 4th, 2025 | ISBN: 1668031248 | 352 pages | True EPUB | 3.87 MB
"Demonstrates how some of the most accomplished and elite scientific gatekeepers may have lied, cheated, squandered trust and endangered lives." -The Wall Street Journal
For readers of Empire of Pain and Dopesick, an arresting deep dive into how Alzheimer's disease treatment has been set back by corrupt researchers, negligent regulators, and the profit motives of Big Pharma.
Nearly seven million Americans live with Alzheimer's disease, a tragedy that is already projected to grow into a $1 trillion crisis by 2050. While families suffer and promises of pharmaceutical breakthroughs keep coming up short, investigative journalist Charles Piller's Doctored shows that we've quite likely been walking the wrong path to finding a cure all along-led astray by a cabal of self-interested researchers, government accomplices, and corporate greed.
Piller begins with a whistleblower-Vanderbilt professor Matthew Schrag-whose work exposed a massive scandal. Schrag found that a University of Minnesota lab led by a precocious young scientist and a Nobel Prize-rumored director delivered apparently falsified data at the heart of the leading hypothesis about the disease. Piller's revelations of Schrag's findings stunned the field and the public.
From there, based on years of investigative reporting, this "seminal account of deceit that will long be remembered" (Katherine Eban, author of Bottle of Lies and Vanity Fair special correspondent) exposes a vast network of deceit and its players, all the way up to the FDA. Piller uncovers evidence that hundreds of important Alzheimer's research papers are based on false data. In the process, he reveals how even against a flood of money and influence, a determined cadre of scientific renegades have fought back to challenge the field's institutional powers in service to science and the tens of thousands of patients who have been drawn into trials to test dubious drugs. It is a shocking tale with huge ramifications not only for Alzheimer's disease, but for scientific research, funding, and oversight at large.
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Averil Cameron, "Doctrine and Debate in the East Christian World, 300-1500 "
English | ISBN: 1409400344 | 2011 | 470 pages | EPUB | 4 MB
The reign of Constantine (306-37), the starting point for the series in which this volume appears, saw Christianity begin its journey from being just one of a number of competing cults to being the official religion of the Roman/Byzantine Empire. The involvement of emperors had the, perhaps inevitable, result of a preoccupation with producing, promoting and enforcing a single agreed version of the Christian creed. Under this pressure Christianity in the East fragmented into different sects, disagreeing over the nature of Christ, but also, in some measure, seeking to resist imperial interference and to elaborate Christianities more reflective of and sensitive to local concerns and cultures. This volume presents an introduction to, and a selection of the key studies on, the ways in which and means by which these Eastern Christianities debated with one another and with their competitors: pagans, Jews, Muslims and Latin Christians. It also includes the iconoclast controversy, which divided parts of the East Christian world in the seventh to ninth centuries, and devotes space both to the methodological tools that evolved in the process of debate and the promulgation of doctrine, and to the literary genres through which the debates were expressed.
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Michael Stevenson, "Doing Media Research"
English | ISBN: 152960205X | 2025 | 312 pages | PDF | 4 MB
What is media research and how is it done? This book offers detailed introductions and practical guidance for all aspects of media research, from developing a research question and choosing sources to interpreting media texts, applying qualitative and quantitative methods, conducting interviews, and much more.
You will encounter:
A ′Fundamentals′ section covering eight big topics like ′what is method?′
A global perspective reflected in case studies of media research in Asia, Africa and South America
Practical examples on topics from crafting a thesis statement to conducting an analysis and presenting the outcomes
Read more
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Amanda Taylor-Beswick, "Doing Phenomenography: A Practical Guide "
English | ISBN: 1447369904 | 2024 | 156 pages | PDF | 10 MB
This practical handbook is aimed at students who are new to phenomenograpy - a popular research method for its versatility in understanding people's perceptions. Enabling readers to decide on the appropriateness of the phenomenographic approach for their own research project, it equips them with the necessary tools to embark on their journey.
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Domain-Driven Design with Golang: Use Golang to create simple, maintainable systems to solve complex business problems by Matthew Boyle
English | December 16, 2022 | ISBN: 1804613452 | 204 pages | EPUB | 7.22 Mb
Understand the concept of Domain-driven design and build two DDD systems from scratch that can be showcased as part of your portfolioKey FeaturesExplore Domain-driven design as a timeless concept and learn how to apply it with GoBuild a domain-driven monolithic application and a microservice from scratchLeverage patterns to make systems scalable, resilient, and maintainableBook Description
Domain-driven design (DDD) is one of the most sought-after skills in the industry. This book provides you with step-by-step explanations of essential concepts and practical examples that will see you introducing DDD in your Go projects in no time. Domain-Driven Design with Golang starts by helping you gain a basic understanding of DDD, and then covers all the important patterns, such as bounded context, ubiquitous language, and aggregates. The latter half of the book deals with the real-world implementation of DDD patterns and teaches you how to build two systems while applying DDD principles, which will be a valuable addition to your portfolio. Finally, you'll find out how to build a microservice, along with learning how DDD-based microservices can be part of a greater distributed system. Although the focus of this book is Golang, by the end of this book you'll be able to confidently use DDD patterns outside of Go and apply them to other languages and even distributed systems.What you will learnGet to grips with domains and the evolution of Domain-driven designWork with stakeholders to manage complex business needsGain a clear understanding of bounded context, services, and value objectsGet up and running with aggregates, factories, repositories, and servicesFind out how to apply DDD to monolithic applications and microservicesDiscover how to implement DDD patterns on distributed systemsUnderstand how Test-driven development and Behavior-driven development can work with DDDWho this book is for
This book is for intermediate-level Go developers who are looking to ensure that they not only write maintainable code, but also deliver great business value. If you have a basic understanding of Go and are interested in learning about Domain-driven design, or you've explored Domain-driven design before but never in the context of Go, then this book will be helpful.Table of ContentsA brief history of Domain Driven DesignUnderstanding Domains, Ubiquitous Language, and Bounded ContextsAggregates, Entities & Value ObjectsFactories, Repositories & ServicesApplying Domain Driven Design to a monolithic applicationBuilding a microservice using domain driven designDomain Driven Design for distributed systemsTDD, BDD and DDD
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Don't Die Diet: Unlock the Secrets to Live Longer and Healthier: A Scientifically Proven Longevity Guide
English | 2025 | ASIN : B0DVSTPB1C | 70 Pages | EPUB | 0.4 MB
Discover the revolutionary approach to health and longevity with Don't Die Diet. Packed with cutting-edge scientific research, practical tips, and inspiring insights, this book is your ultimate guide to transforming your life-one meal at a time.
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Sarah Noll Wilson, "Don't Feed the Elephants!: Overcoming the Art of Avoidance to Build Powerful Partnerships"
English | ISBN: 1544524501 | 2022 | 294 pages | EPUB | 2 MB
You see the giant footprints the moment you walk through the door. The conference room is a swirling mess of tension, heaviness, anxiety, and peanut shells. Something is very wrong with your team. Everybody knows it, but nobody is talking about it.
It's obvious there's an elephant in the room. Is it an Avoidephant, feeding off the fears of retaliation and exclusion? Perhaps it's a Blamephant-whom we love to feed because it makes us feel better about ourselves. Or is it one of the other five types of elephants?
No matter what type you're dealing with, executive coach Sarah Noll Wilson knows your elephant is not there by accident. It was created, and someone has been feeding it. Is it you?
Read more
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Don't Squish a Slug: A Wonderful Celebration of Marvellous Minibeasts! by Yussef Rafik
English | February 18th, 2025 | ISBN: 0711293449 | 66 pages | True PDF | 38.88 MB
Learn all about how amazing bugs and minibeasts are in this detailed guide to over 40 small creatures from around the world. Bugs and minibeasts may be small, sometimes slimy, and maybe a little scary, but they are AMAZING and deserve respect and empathy.
Don't Squish A Slug will show you everything you need to know, and more, about why bugs are the most important creatures on the planet, even if they may not look it!
For example, did you know that there are bugs who. . .
* Use disguise to blend in with their surroundings,
* Bugs who have come up with clever defence tactics to keep themselves safe,
* AND bugs who have broken world records?
Or, did you know that. . .
* The Taurus Scarab Beetle is the strongest insect in the world and can pull 1,141 times its own body weight - which is the equivalent of a human lifting six double-decker buses!
* Or. . . that the Banana Slug has anesthetic slime, so if you were to lick one your tongue would go numb!
Learn about how awe-inspiring bugs really are in Don't Squish A Slug. Written by zoologist, conservationist and wildlife TV presenter Yussef Rafik and illustrated by Riley Samels (who makes every bug look cool), Dont Squish A Slug is a treasure-trove of expert information and quirky, retro illustrations for young readers to enjoy.
So. . . don't squash a spider, don't step on ants and definitely don't squish a slug!
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Don't Waste Your Pumpkin: Innovative recipes and projects, from stalk to base by Emily Gussin
English | August 13, 2024 | ISBN: 176150035X | 112 pages | MOBI | 4.37 Mb
Supermarkets are stuffed full of pumpkins in the run-up to Halloween. So many people just carve them for Jack-o'-lanterns then throw away the seeds and leftover flesh, not knowing how easily they can be cooked and eaten.
Don't Waste Your Pumpkin offers all sorts of tasty recipes to make use of every part of the pumpkin and majors on avoiding waste. There are also simple craft projects to take you beyond the usual carving traditions and celebrate all kinds of pumpkin.
There's so much more to the cosy autumn season than pumpkin spice!
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Donor-Acceptor Cyclopropanes in Organic Synthesis by Prabal Banerjee, Akkattu T. Biju
English | February 5, 2024 | ISBN: 3527349871 | 464 pages | MOBI | 55 Mb
Facilitate milder, simpler reactions in organic synthesis with this cutting-edge family of building blocks
Donor-Accepted Cyclopropanes, or DACs, have attracted a resurgence of interest from organic chemists in recent decades for their role in facilitating various reactions such as cycloadditions, annulations, ring-opening and enantioselective transformations. The structural arrangement of DACs leads to milder, simpler reaction conditions, which have made them indispensable for a range of fundamentally and industrially important processes.
Donor-Acceptor Cyclopropanes in Organic Synthesis covers comprehensively the chemistry and applications of this compound class. The result is an invaluable guide for any researcher looking to bring DACs to bear in their own areas of research or development.
Readers will also find:A brief introduction of the history and reactivity of DACsDetailed discussion of reactions including Lewis acid-catalyzed cycloadditions, metal-free activation, asymmetric transformations, organocatalysis, and many moreApplication of DACs in natural product synthesis and pharmaceutical/agrochemical researchDonor-Acceptor Cyclopropanes in Organic Synthesis is ideal for organic chemists, experts in catalysis, pharmaceutical researchers, and any other scientists interested in facilitating milder, simpler reactions.
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Dopamina Detox: La Guida Definitiva: Elimina le Distrazioni e Riaccendi la Motivazione
Italiano | 2025 | ASIN: B0DX75L6R2 | 223 Pages | EPUB | 0.2 MB
Se avete risposto sì a una di queste domande, il vostro cervello è in uno stato di sovrastimolazione della dopamina . Il bombardamento continuo di informazioni e gratificazioni istantanee riduce la vostra capacità di mantenere la concentrazione e la concentrazione , lasciandovi intrappolati in un circolo vizioso di dipendenza digitale e procrastinazione .
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Double Agent Balloon: Dickie Metcalfe's Espionage Career for MI5 and the Nazis by David Tremain
English | May 4, 2023 | ISBN: 1399061097 | 264 pages | PDF | 0.47 Mb
Dickie Metcalfe was not your typical secret agent, but he was larger than life in more ways than one. Unlike many other agents who were part of the Double Cross System during the Second World War, he did not defect; nor was he blackmailed into becoming a spy. Instead, using his father's connection with Sir Vernon Kell, the first Director of MI5, Metcalfe volunteered his services.
Recently cashiered from his infantry regiment, he had an ulterior motive - by supplying MI5 with tidbits of information about weapons and arms deals in his newfound profession as an arms dealer, he hoped they would be able to help him get his commission reinstated. Metcalfe became BALLOON, a sub-agent of double agent TRICYCLE's Yugoslav spy ring.
Concurrent with his spying activities, he collaborated with the co-inventor of the Bren gun to develop a new submachine gun for British forces. After the war, he was also a celebrated motor racing driver and continued to compete until shortly before his death. His success as a double-cross agent in the eyes of both his masters - British and German - is examined in this book, using official documents as a primary source.
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Dr. Calhoun's Mousery: The Strange Tale of a Celebrated Scientist, a Rodent Dystopia, and the Future of Humanity by Lee Alan Dugatkin
English | October 3, 2024 | ISBN: 0226827852 | 240 pages | PDF | 4.85 Mb
"Brilliant. . . . An absorbing read and a potent lesson in moral behavior-both of rodents and of humans."-Deborah Blum, Pulitzer Prize-winning author of The Poison Squad
* "A fascinating read about an immensely influential scientist."-Robert M. Sapolsky, author of the New York Times-bestseller Determined
* "Stimulating scientific history. . . . Colorful accounts. . . . This fascinates."-
Publishers WeeklyA bizarre and compelling biography of a scientist and his work, using rodent cities to question the potential catastrophes of human overpopulation.
It was the strangest of experiments. What began as a utopian environment, where mice had sumptuous accommodations, had all the food and water they could want, and were free from disease and predators, turned into a mouse hell. Science writer and animal behaviorist Lee Alan Dugatkin introduces readers to the peculiar work of rodent researcher John Bumpass Calhoun. In this enthralling tale, Dugatkin shows how an ecologist-turned-psychologist-turned-futurist became a science rock star embedded in the culture of the 1960s and 1970s. As interest grew in his rodent cities, Calhoun was courted by city planners and his work was reflected in everything from Tom Wolfe's hard-hitting writing to the children's book Mrs. Frisby and the Rats of NIMH. He was invited to meetings with the Royal Society and the pope and taken seriously when he proposed a worldwide cybernetic brain-a decade before others made the internet a reality.
Readers see how Calhoun's experiments-rodent apartment complexes like "Mouse Universe 25"-led to his concept of "behavioral sinks" with real effects on public policy discussions. Overpopulation in Calhoun's mouse (and rat) complexes led to the loss of sex drive, the absence of maternal care, and a class of automatons that included "the beautiful ones," who spent their time grooming themselves while shunning socialization. Calhoun-and those who followed his work-saw the collapse of this mouse population as a harbinger of the ill effects of an overpopulated human world.
Drawing on previously unpublished archival research and interviews with Calhoun's family and former colleagues, Dugatkin offers a riveting account of an intriguing scientific figure. Considering Dr. Calhoun's experiments, he explores the changing nature of scientific research and delves into what the study of animal behavior can teach us about ourselves.
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Dragon Food: 70 Legendary, Magical, and Fantasy-Inspired Recipes (Whimsical Treats) by Cayla Gallagher
English | September 3, 2024 | ISBN: 1510776990 | 176 pages | MOBI | 28 Mb
Enter a world where dragons and griffins roam free-and are super delicious!
Wander through the enchanted forest and snack on some Matcha Dragon Donuts, bravely fight your way past the 3D Dragon Egg Cake, over some Edible Moss and Edible Embers to steal the Dragon's Golden Coins! Purchase some Dragon Scale Dust, Dragon Extract, and Dragon's Breath at the Magic Market, then summon a Loch Ness Monster Trifle from the sea or some Peanut Brittle Dragon Wings from the sky. Make your wildest fantasies a reality with this fun, mystical cookbook!
These legendary beasts can take the forms of lollipops, cupcakes, cookies, pie, 3D cakes, donuts, truffles, and more with Cayla Gallagher's newest book in her Whimsical Treats series.
Sections include:Enchanted ForestDragon's LairThe Magic MarketUnder the SeaUp in the CloudsThis collection will impress all ages of fantasy fans with a sweet tooth. It's perfect for your next watch party, movie night, or game night-and don't forget about the birthday parties!
Don't miss Cayla's other imaginative books in this collection: Unicorn Food,Mermaid Food,Spooky Food,Reindeer Food, andElf Food.
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Dragon Tactics: How Chinese Entrepreneurs Thrive in Uncertainty by Aldo Spaanjaars, Sandrine Zerbib
English | August 30th, 2022 | ISBN: 9063696388 | 240 pages | True EPUB | 2.59 MB
In business, change is the only constant. Dragon Tactics demonstrates that Chinese entrepreneurs know how to thrive in uncertainty. The book contains many lessons for Western leaders to learn how to ride the wave of change.
Global conflicts, environmental challenges and rapid digitization are just some of the unpredictable factors that are putting increasing strain on traditional business models. Chinese entrepreneurs know how to thrive in uncertainty: they have grown their business in an environment that has taught them to adapt often, thrive in chaos and overcome constant challenges of uncertainty.
* Learn how to better navigate an increasingly uncertain and volatile world far beyond China's borders.
* Masters skills that are rooted in China's four-thousand-year-old history and culture.
* Read about management methods that borrow as much from Confucianism as from new technologies.
* Written by business experts and China veterans Aldo Spaanjaars and Sandrine Zerbib.
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Draw Amazing Faces: Learn the Basics and Develop Your Own Style by Pypah Santos
English | October 22, 2024 | ISBN: 0760389217 | 144 pages | MOBI | 18 Mb
Create stunning portraits while developing your own remarkable artistic style with this practical, inspiring, and easy-to-follow guide.
Draw Amazing Faces is your go-to reference for crafting stunning portraits from scratch. Join Pypah Santos, the celebrated artist and YouTube sensation, as she unveils:
Step-by-step guidance for constructing heads from diverse angles, mastering proportions, sketching facial features, and eliciting a spectrum of expressionsTechniques for both male and female faces of different agesSignature techniques for rendering hair, including different types, textures, and stylesShading and rendering techniques that infuse vitality into your portraitsInspiration for developing your distinct style in portraying fantastic facesQR codes linked to videos that further demonstrate important techniquesDraw Amazing Faces is your passport to the captivating world of portraiture. With Pypah's expertise, you will master the intricacies of portraying faces using her straightforward techniques. Whether you're a fine artist, illustrator, comic book artist, you will elevate your artistry, infuse life into your sketches, and uncover your distinct style, all while honing your ability to create awe-inspiring, lifelike faces.
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Draw the Great Outdoors!: Doodle Easy Landscapes with Just a Pen by Harrison How
English | October 22, 2024 | ISBN: N/A | ASIN: B0CPWSYWBT | 300 pages | EPUB | 64 Mb
GRAB A PEN, ADVENTURE AWAITS!
Explore all the beauty nature has to offer with 20 awe-inspiring land and seascape sketches. In this accessible, step-by-step guide, artist and nature enthusiast Harrison How shows you how to effortlessly capture the ancient wonders of the world in stunning panoramas. Harness the tenacious spirit of the arid deserts as you form Ever Shifting Sand Dunes. Hear the call of the wild as you chart the weathered rock and eroded slopes of the world's most dramatic mountain peaks with Majestic Volcanos or Cliffs and Rocky Ranges. Unearth the mysteries that hide beneath the waves in Otherworldy Tide Pools.
Harrison breaks the most complicated scenes into mini-tutorials so you can master every detail with ease. You'll also learn how to seamlessly layer everything together from the smallest shrubs to the largest canyons for picture-perfect drawings. No matter your age or skill level, all you need is a pen to bring the outdoors to life.
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Drawing Amazing Optical Illusions: Easy Lessons for Drawing 3D Trick Art Step-by-Step by Tom McPherson
English | July 15th, 2024 | ISBN: 9798888141564 | 192 pages | True EPUB (Retail Copy) | 54.43 MB
Create mind-blowing artwork that pops off the page!
Drawing complex three-dimensional art does not have to be intimidating. It may seem difficult or only for the advanced artist, but in this book author Tom McPherson breaks down in simple step-by-step instructions how anyone can create detailed, mesmerizing optical illusions even with little drawing experience.
In this groundbreaking book, McPherson details how to create cool artwork from scratch by learning basic drawing techniques and progressing to more complex skills and creations, including:
* Impossible Shapes: Optical 3D illusions of shapes that could not exist in reality
* Floating Shapes: Solid shapes that look like they hover above the paper
* 3D Line Art: Inventive 3D illusions on simple lined paper
* Anamorphic Buildings: Subjects drawn with extreme distortion that look realistic and 3D
* 5-Point Perspective: Drawing 3D fisheye views using perspective and curved lines
* And much more! This is the ultimate guide to mastering trick drawing and creating cool images that will impress your friends and family.
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Riccardo Moratto, "Dream of the Red Chamber "
English | ISBN: 1032284315 | 2024 | 266 pages | PDF | 8 MB
This edited volume contains an excellent collection of contributions and presents various informative topics under the central theme: literary and translation approaches to China's greatest classical novel Hongloumeng.
Acclaimed as one of the Four Great Classical Novels of Chinese literature, Hongloumeng (known in English as The Dream of the Red Chamber or The Story of the Stone) epitomizes 18th century Chinese social and cultural life. Owing to its kaleidoscopic description of Chinese life and culture, the novel has also exerted a significant impact on world literature. Its various translations, either full-length or abridged, have been widely read by an international audience. The contributors to this volume provide a renewed perspective into Hongloumeng studies by bringing together scholarship in the fields of literary and translation studies. Specifically, the use of corpora in the framework of digital humanities in a number of chapters helps re-address many issues of the novel and its translations, from an innovative angle.
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Jesse Keskiaho, "Dreams and Visions in the Early Middle Ages: The Reception and Use of Patristic Ideas, 400-900 "
English | ISBN: 1107082137 | 2015 | 340 pages | EPUB | 1081 KB
Dreams and visions played important roles in the Christian cultures of the early Middle Ages. But not only did tradition and authoritative texts teach that some dreams were divine: some also pointed out that this was not always the case. Exploring a broad range of narrative sources and manuscripts, Jesse Keskiaho investigates how the teachings of Augustine of Hippo and Pope Gregory the Great on dreams and visions were read and used in different contexts. Keskiaho argues that the early medieval processes of reception in a sense created patristic opinion about dreams and visions, resulting in a set of authoritative ideas that could be used both to defend and to question reports of individual visionary experiences. This book is a major contribution to discussions about the intellectual place of dreams and visions in the early Middle Ages, and underlines the creative nature of early medieval engagement with authoritative texts.
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